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Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Summer 2002 , Volume 6 , Number 2; Page(s) 13 To 19.
 
Paper: 

COMPARING THE ANTI-TYPE 2 COLLAGEN ANTIBODY TITER IN RHEUMATOID FACTOR NEGATIVE VS. RHEUMATOID FACTOR POSITIVE SERA

 
 
Author(s):  KARIMI FOROUZAN, FIROOZMANESH N.
 
* 
 
Abstract: 

Introduction and Objectives: This study was done to determine the anti-type 2 collagen (anti cII) antibody titer in rheumatoid factor negative (RF-) vs. rheumatoid factor positive (RF+) sera.
Materials and Methods: 77 RF+ and 221 RF- sera were examined for presence and titer of anti-type 2 collagen antibody, using the tannic acid hemagglutination method.
Results: Anti cII antibody was found in 67.5% and 57.9% of RF+ and RF- cases, respectively. There was no significant difference between RF- vs. RF+ sera regarding the presence of anti cII antibody. However, there was a significant difference (p<0.001) between RF- vs. RF+ sera regarding the titer of anti cII antibody, with significantly higher antibody levels in RF+ sera.
Discussion and Conclusions: We suggest further studying the correlation between anti cII antibody, RF, and disease severity in rheumatoid arthritis is worthwhile.

 
Keyword(s): COLLAGEN, AUTOIMMUNITY, RHEUMATOID FACTOR
 
References: 
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