Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Summer 2002 , Volume 6 , Number 2; Page(s) 1 To 8.
 
Paper: 

EFFECTS OF ALKYLBENZENE SULFONATE ON RAT S BRAIN AMP DEAMINASE ACTIVITY

 
 
Author(s):  GHOUJAGH D., GHAZI MIRSAEED M.A., AHANJAN M.
 
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Abstract: 

Introduction and Objective: Alkylbenzene sulfonate is used as surfactant and, being discarded into rivers; it acts as an environmental pollutant. The enzyme AMP deaminase may be potentially useful in delineating the possible mechanisms of biological toxicity of alkylbenzene sulfonate.
Materials and Methods: We studied the effects of alkylbenzene sulfonate on rats brain AMP deaminase activity by measuring (with spectrophotometry) the enzyme activity with and without exposure to 5-10 micromole concentrations of alkylbenzene sulfonate, using 30 specimens in each study arm. Results: Enzyme activity in presence and absence of exposure to alkylbenzene sulfonate was 92.85±8.52 and 18.31±2.45 nmol/min/gr brain protein, respectively.
Discussion and Conclusions: Alkylbenzene sulfonate may inhibit AMP deaminase by reacting to its active site. Our results may be used to understand the toxicity of alkylbenzene sulfonate.

 
Keyword(s): ALKYLBENZENE SULFONATE, AMP DEAMINASE, ENVIRONMENTAL POLLUTANT
 
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