Paper Information

Journal:   UROLOGY JOURNAL   Summer 2004 , Volume 1 , Number 3; Page(s) 204 To 207.
 
Paper: 

A COMPARISON STUDY BETWEEN THEOPHYLLINE AND PLACEBO IN PASSAGE OF URETERAL STONES

 
 
Author(s):  TADAYYON F., YAZDAN BOUD M., EBADZADEH M.R.
 
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Abstract: 
Purpose: Considering the high prevalence of urinary ~ystem stones and that nonmedical treatments have more costs ana side effects, we decided to evaluate the effect of theophylline in the passage of ureteral stones. Materials and Methods: One hundred and fifty patients with ureteral stones were assigned into groups A and B, whose 1ige,sex, size of stone, and location of stone were matched together. Patients ages ranged from 17 to 67 years. In group A theophylline (200 mg BID) was administered and group B received placebo for six weeks. Both groups were followed up by visits every fortnight and radiological assessment was performed at the end of the sixth week. The proportion of patients whose stones were passed was compared between the two groups. Result: In group A with theophylline consumption 46 out of 75 (61.3%) passed their stones. The mean duration between the initiation of the treatment with theophylline and stone passage was18.3 days. In group B with placebo, the stone passage occurred in 31 out of 75 (41.3%) patients (p<0.032) and the mean duration was 24.8 days (p<0.05). Conclusion: With regard to the findings of this study, it seems that theophylline can increase the rate of ureteral stone passage and as well, accelerate it.
 
Keyword(s): THEOPHYLLINE, UROLITHIASIS, STONE PASSAGE
 
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