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Paper Information

Journal:   JOURNAL OF CURRENT OPHTHALMOLOGY   2004 , Volume 17 , Number 2; Page(s) 76 To 82.
 
Paper: 

ROLE OF PROPHYLACTIC INTRACAMERAL R-TPA IN PREVENTION OF FIBRINOUS REACTION AFTER CONGENITAL CATARACT SURGERY WITH IOL IMPLANTATION: A DOUBLE-MASKED RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  PIRI N., SIATIRI H., ASGHARI H.*, BEHBAHANI NEJAD M.
 
* Farabi Hospital, Tehran University of Medical Sciences
 
Abstract: 

Purpose: To evaluate the efficacy of intracameral recombinant tissue plasminogen activator in prevention of fibrinous effusion after lensectomy, anterior vitrectomy and PC IOL implantation in patients with congenital cataract.
Methods: The study was done as a double-masked randomized clinical trial. Between April 2002 and Nov 2003, 34 eyes from 26 patients with congenital cataract were included in the study and randomized into two groups (18 cases & 16 controls). Each eye underwent lensectomy and anterior vitrectomy with PC IOL implantation. At the end of surgery 20 μg r-TPA was injected intracamerally in case group. No injection was done in control group. All patients received periocular, systemic and topical steroids after surgery. Follow up examinations were done in the following 3 months.
Results: The incidence of intraocular fibrin membrane formation was significantly lower in case group on days 1 (P=0.024), 3 (p=0.01), 7 (P=0.01), 14 (P=0.01); but there was no significant difference on days 30 and 90. The frequency of pigmented IOL precipitates were significantly lower in case group at the end of third month (P<0.001). No gross ocular side effects were noted after r-TPA injection.
Conclusion: It seems that prophylactic intracameral r-TPA is effective in prevention of fibrinous effusion at least in the first two weeks after cataract extraction in pediatric age group and decreases incidence of pigmented IOL precipitates.

 
Keyword(s): CONGENITAL CATARACT, FIBRINOUS EFFUSION, INTRACAMERALLNJECTION, PROPHYLAXIS, R-TPA
 
References: 
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  Persian Abstract Yearly Visit 76
 
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