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Paper Information

Journal:   JOURNAL OF CURRENT OPHTHALMOLOGY   2004 , Volume 17 , Number 1; Page(s) 5 To 12.
 
Paper: 

PROPHYLACTIC INTRAOCULAR GENTAMICIN AND CLINDAMYCIN IN PREVENTION OF ACUTE POSTTRAUMATIC ENDOPHTHALMITIS AFTER PENETRATING OCULAR INJURIES: A DOUBLE-MASKED RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  NILI AHMAD ABADI M.*, MOVASAT M., TABATABAEI S.A., RIAZI ESFAHANI M., MIRSHAHI A., PIRI N., ASGHARI H., FAGHIHI-HABIBABADI H., LASHEYEI A.R., MANSOURI M.R., FARAHVASH M.S., KARKHANEH R., JAVADIAN A.
 
* Tehran University of Medical Sciences, Farabi Hospital, Eye Research Center
 
Abstract: 

Purpose: To evaluate the efficacy of intraocular Gentamicin and Clindamycin in prevention of acute posttraumatic bacterial endophthlamitis following penetrating ocular injuries.
Desigin: Randomized Clinical Trial (Double-masked)
Methods: 177 eyes of 177 patients with penetrating ocular injuries were enrolled. Following primary repair, the eyes were randomized in two groups; eyes in the antibiotic injection group were given intracameral or intravitreal injection of 0.1 mL antibiotic (40µg Gentamicin and 45 µg Clindamycin). Eyes in the control group were given no intraocular injections. All patients received standard prophylactic antibiotic therapy (systemic, subconjunctival, and topical).
Results: The overall incidence of endophthalmitis was 2.3% (4 of 177 eyes). All endophthalmitis cases occurred in the control group (P=0.029). The incidence of endophthalmitis was higher in those who had intraocular foreign bodies (P<0.001), in those with posterior lens capsule rupture (P=0.002), and in eyes with vitreous penetration (P=0.02).
Conclusion: Intraocular injection of Gentamicin and Clindamycin seems to be an effective procedure in prevention of acute posttraumatic endophthalmitis.

 
Keyword(s): CLINDAMYCIN, ENDOPHTHALMITIS, GENTAMICIN, PENETRATING TRAUMA, PROPHYLAXIS
 
References: 
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