Paper Information

Journal:   IRANIAN POLYMER JOURNAL (ENGLISH)   July-Agust 2003 , Volume 12 , Number 4; Page(s) 315 To 322.
 
Paper: 

FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS

 
 
Author(s):  KHORAM M., VASHEGHANI FARAAHANI E.*, GOLSHAN EBRAHIMI N.
 
* DEPARTMENT OF CHEMICAL ENGINEERING, TARBIAT MODARRES UNIVERSITY,TEHRAN, I.R. IRAN
 
Abstract: 

Ionic and non-ionic temperature sensitive hydrogels of poly(N-isopropylacrylamide) and calcium alginate were prepared as interpenetrating networks. Calcium alginate was used as a mould to prepare uniform, large size, spherical beads and then extracted to leave a macroporous structure. Swelling behaviour, and drug release kinetics of these thermosensitive hydrogels were studied in aqueous media. The swelling observations indicated that equilibrium swelling degree of homopolymer gel increased after extraction of calcium alginate, and also calcium alginate had no effect on lower critical solution temperature (LCST). In addition, equilibrium swelling degree of copolymer hydrogels containing Na+, and Ca2+ cations were greater than that of the extracted hydrogel containing only monovalent cations. It was observed that, swelling kinetics of hydrogels followed a Fickian behaviour. Drug release experiments indicated that drug release from these hydrogels was fast and in Fickian manner.

 
Keyword(s): HYDROGELS, N-ISOPROPYLACRYLAMIDE, FAST RESPONSIVE, DRUG DELIVERY, CALCIUM ALGINATE
 
References: 
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