Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Fall 2001 , Volume 8 , Number 3 (SN 21); Page(s) 25 To 31.
 
Paper: 

A HISTOPATHOLOGICAL STUDY OF EFFECTS OF INTRAPERITONEAL GARLIC EXTRACT ON LIVER IN RATS

 
 
Author(s):  GHAFOURIAN BOROUJERDNIA M.*
 
* DEPARTMENT OF IMMUNOLOGY, SCHOOL OF MEDICINE, KHOZESTAN UNIVERSITY OF MEDICAL SCIENCES & HEALTH SERVICES, AHVAZ, IRAN
 
Abstract: 

In recent years, many investigations have reported the pharmaceutical effects of garlic such as antibacterial, antihypertension, antithrombotic, anticarcinogenic and many others. Studies suggest that garlic may have toxic effects on body tissues. In this study, histopathological effects of garlic extract on liver tissue in rats were investigated.
The animals were divided into five groups including control group (received saline) and four experimental groups (received garlic extract, 50, 100, 200 and 400 mg/kg intraperitonally for a month). The sections of liver tissue were stained by H&E method for histopathological examination.
The histopathological examination indicated that administration of low dose of garlic (50 mg/Kg) has little effects on liver tissue in comparison with the control animals. However, administration of high dose of garlic (400 mg/kg) induces considerable damage on this tissue in comparison to other groups.
Although the use of garlic is useful for body, the consumption of high levels of garlic may induce toxic effects on body tissues. Therefore, further studies are needed before garlic preparations can be used as medicine.

 
Keyword(s): GARLIC, LIVER - PATHOLOGY, RATS
 
References: 
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