Paper Information

Journal:   IRANIAN POLYMER JOURNAL (ENGLISH)   March-April 2003 , Volume 12 , Number 2; Page(s) 147 To 152.
 
Paper: 

COATING OF POLYESTER FABRICS WITH GRAPHITE COMPOSITION TO PRODUCE THROMBORESISTANT VASCULAR GRAFTS PART I: COATING TECHNIQUE AND IN VITRO STUDY

 
 
Author(s):  ARABI HASAN, MIRZADEH HAMID*, AHMADI S.H., AMANPOUR S.
 
* Department of Polymer Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, I.R. Iran
 
Abstract: 

The purpose of this study was to develop a homogeneous and stable graphite sealant that seals polyester vascular grafts to improve the thromboresistant of grafts. Water colloid dispersion of graphites were prepared using graphite (1-3), sugar, gelatin and double distillated water. The knitted crimped polyester fabric vascular grafts with 10 and 12 mm inside diameter were coated via electrophoresis method using water colloid dispersion of graphite. Several mechanical cleanings were carried out on grafts and then the grafts were heated for 2 h at 150°C. The number of adhered platelets was determined by lactate dehydrogenase (LDH) activity measurement. Scanning electron microscopy (SEM) was performed on the graphite coated for evaluating the morphology of vascular grafts surface and also studying the morphology of adhered platelet to polyester fabric grafts. The results showed homogeneous coating of graphite on polyester vascular grafts. SEM observations showed that the platelet adhesion on non-coated vascular grafts surface were relatively high in comparison with the graphite coated fabrics. It was also observed that the graphite coating on polyester vascular grafts reduced the number of adherent platelets and prevents platelet activation and spreading on the surface. Reduction of platelet adhesion was attributed to the coated surfaces.

 
Keyword(s): VASCULAR GRAFT, POLYESTER, GRAPHITE COATING, ELECTROPHORESIS, PLATELET ADHESION
 
References: 
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