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Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   December 2002 , Volume - , Number 54; Page(s) 31 To 38.
 
Paper: 

EVALUATION OF ACUTE AFLATOXICOSIS ON HUMORAL IMMUNE RESPONSE TO FOOT-AND-MOUTH DISEASE VACCINATION IN GUINEA PIGS

 
 
Author(s):  SHAH SAVANDI SH.*, EBRAHIMI M.M., SALEHIZADEH M., IZADI H.
 
* FOOT-AND-MOUTH DISEASE VACCINE RESEARCH & PRODUCTION DEPT., RAZI INSTITUTE, TEHRAN, IRAN
 
Abstract: 

The immunosuppression of aflatoxinB1 (AFB1) on humoral immune response to foot-and-mouth disease (FMD) vaccination was evaluated. Fifty-two male guinea pigs were assigned to two treatment groups of 20 (A, B) and three control groups of 4. Groups A and B were vaccinated with an inactivated FMD vaccine after they were dosed 0.63mg of AFB1/Kg once, and on days 1, 3, 14 and 21 respectively. Booster doses were injected 28 days after primary vaccination. Antibody titers against FMD virus were higher in the vaccinated, non-aflatoxin exposed group than in those exposed to aflatoxin. Significantly difference (P<0.05) was detected only in-group B that was shown an average weight loss of 25g and persisted through second vaccination. The result indicates that aflatoxin can depress the humoral immune responses of guinea pigs to FMD vaccination and the immunotoxicity was found to be dose related.

 
Keyword(s): AFLATOXIN, FOOT-AND-MOUTH DISEASE, VACCINATION, IMMUNOSUPPRESSION
 
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