Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Spring 2002 , Volume 9 , Number 1 (SN 23); Page(s) 27 To 31.
 
Paper: 

THE ELECTROPHORETICAL PATTERN OF PREMATURE PLACENTAL COLLAGENS

 
 
Author(s):  POURKABIR R.*, MALEKNIA N., PASALAR P.
 
* Department of Biochemistry & Nutrition, School of Medicine, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran
 
Abstract: 

Serveral different types of collagen have been identified invivo. Human placenta has been employed by a number of investigators over the past decade as a starting material for isolation and characterization of different genetic types of collagen including type I, III, IV and IV molecules.
Proteases of the placenta participate in the degradation of intracellular and extracelluar matrix proteins. To extract collagen types IV and I+III, a healthy placenta at term (38 weeks) and a premature placenta (14 weeks) were placed under pepsin digestion using minimum quantity. The steps of extraction were controlled by the SDS-PAGE.
The electrophoretical patterns of premature placental collagen indicated that the number of collagen chains types IV and I+III in premature placenta were less than that of the healthy placenta at term. According to electrophoretical pattern in the premature placenta , there were not 2 (IV) , 11 (I) , 12 (I) and 1 (III) chains. Thus, it is probable that in some of the repeating abortion the synthesis of collagen is decreased or degradation of collagen is increased.
So it is suggested to measure the serum and cervix collagenase in women who had unexplained abortions.

 
Keyword(s): COLLAGEN, ELECTROPHORESIS, PLACENTA
 
References: 
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