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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Spring 2001 , Volume 8 , Number 1 (SN 19); Page(s) 5 To 8.
 
Paper: 

COMPARISON OF THERAPEUTIC EFFECT OF INTRAVENOUS GAMMAGLOBULINE WITH KETOGENIC DIET IN CHILDREN WITH REFRACTORY EPILEPSY

 
 
Author(s):  GHOFRANI M.*, TALEBIAN A., MOSTAGHIMI P.
 
* Department of Pediatrics, School of Medicine, Kashan University of Medical Sciences & Health Services, Kashan, Iran
 
Abstract: 

Since of seizures in epileptic is in childhood in 80% of cases and 10 to 20% of these seizures are refractory to treatment, this study was performed to compare the efficacy of intravenous gammaglobuline with ketogenic diet in the treatment of refractory epilepsy in children. A clinical trial research was conducted on 40 children with recalcitrant epilepsy referred to Mophid Children Hospital in 1994. The children were devided to two "Case" and "Control" groups at random after partial matching. Children in the case group were treated by IV gammaglobuline at a dose of 4oo mg/kg/dose each three to four weeks for four to six times and those in the control group by mixed Ketogenic diet. The frequency and duration of seizure, electroencephalografic and behavioral changes before and after therapy were recorded and the result were evaluated. There was a 52% and 64% decrease in the average frequency of seizures per 24-hour in the case and control groups, respectively. The difference was not statistically significant. The duration of seizures was decreased in 45% and 60% of the case and control groups respectively. Since there was no significant difference in the efficacy of these two therapeutic modalities and considering the easier and the modalities , and considering the easier and the more tolerable nature of IV gammaglobuline, this method can be used as a therapeutic modality in recalcitrant epilepsy.

 
Keyword(s): EPILEPSY - DIET THERAPY, GAMMAGLOBULINE, KETOGENIC DIET
 
References: 
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