Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Spring 2001 , Volume 8 , Number 1 (SN 19); Page(s) 43 To 46.
 
Paper: 

THE COMPARISON OF SERUM TRYPSIN INHIBITORY CAPACITY( TIC )IN SERUM HYPERTHYROID PATIENTS WITH CONTROL GROUP(EUTHYROID)

 
 
Author(s):  KHEYR ELAH A.R.*
 
* Department of Biochemistry, School of Medicine, Khozestan University of Medical Sciences & Health Services, Ahvaz, Iran
 
Abstract: 

Alpha-1-AntiTrypsin (α1-AT) is an inhibitory α1- Protease, and belongs to complex protein of glycoprotein type. From the activity point of view, it belongs to Seiren protease inhibitors (serpin). There are many reports in litreture concerning a decrease in the amount of α1-AT in patients with emphysema, skin disorders, adult liver disease, hypothyroidism, and so on. In hypothyroidic patients along with a decrease in the amount of T3, there is a significant decrease in the amount of α1-AT and consequently in the amount of TIC. Therefore, it can be expected that, in hyperthyroidic an increase in the amount of T3 results in an increase in the amounts of a1- AT and TIC. In this study, changes in TIC in hyperthyroidic patients in comparison with a control group was investigated. Measurements were performed on 72 samples, and by using T- test and determination of correlation coeffiecint, the above mentioned changes were analyzed. The results showed that TIC in hyperthyroidic patients (n= 42) had increased in comparison with the control group (n=30), (n=42, TIC=2.54 ± 0.414 mg/ml Vs n= 30, TIC= 1.87 ± 0.29 mg/ml). It was observed that in hyperthyroidic patients, there is a positive correlation between the amounts of T3 and TIC (r=0.71, p<0.0001). Therefore, it can be concluded that trypsin inhibitory capacity and α1-AT concentration had increased in hyperthyroidic patients.

 
Keyword(s): ALPHA 1 - ANTITRYPSIN, HYPERTHYROID, TRYPSIN INHIBITORS
 
References: 
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