Paper Information

Journal:   IRANIAN POLYMER JOURNAL (ENGLISH)   May-June 2004 , Volume 13 , Number 3; Page(s) 189 To 203.
 
Paper: 

SYNTHESIS AND SWELLING KINETICS OF A PH-SENSITIVE TERPOLYMERIC HYDROGEL SYSTEM

 
 
Author(s):  BAJPAI S.K.*, DUBEY S.
 
* Department of Chemistry, Government Autonomous Science College Jabalpur (M.P.) 482001, India
 
Abstract: 

We have developed a pH-sensitive terpolymeric hydrogel system based on acrylamide, methacrylamide and acrylic acid by aqueous polymerization. The hydrogels exhibited a fair pH-dependent swelling behaviour with transition from Fickian (n = 0.43) to non- Fickian (n = 0.83) as the pH of the swelling medium varied from 1.0 to 8.0. The gel exhibited a number of swelling-deswelling cycles as the pH of the swelling medium was varied from 7.4 to 1.0. The equilibrium water uptake was found to increase with the amount of acrylic acid in the gels when studied in the media of pH 7.4. However, at pH 1.0, the degree of swelling was observed to decrease with monomer acid content. The activation energy for the swelling process, as calculated from the Arrehenius plot, was found to be 15.52 kJ mol-1. The gel also showed a good swelling response when put in the media of continuous varying pH. The minimum swelling in the acidic pH was explained on the basis of formation of complex structure within the gel network due to H-bonding interactions between -COOH and -CONH2 groups.

 
Keyword(s): TERPOLYMERIC HYDROGEL, COLON, DRUG-DELIVERY, PH-DEPENDENT SWELLING, ACRYLIC ACID
 
References: 
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