Paper Information

Journal:   HORMOZGAN MEDICAL JOURNAL   Spring 2003 , Volume 7 , Number 1; Page(s) 11 To 16.
 
Paper: 

EFFECT OF ALUMINUM CHLORIDE ON UTERINE CONTRACTION OF RATS

 
 
Author(s):  GHARIB NASERI MOHAMMAD KAZEM*, MOTAEI M., ZAHEDIASL S.
 
* Department Of Physiology, Ahwaz University Of Medical Sciences, Ahwaz, Iran
 
Abstract: 

Introduction: The main sources of Aluminum are foods, water, air and some medications like antacids. One of the side effects of antacid is constipation, which is caused by gastrointestinal motility reduction. Aluminum is known as a potent and irreversible calcium inward current blocker in some mammalian neurons. On the other hand, potassium chloride (KCl), oxytocin (OT) and acetylcholine (Ach) are well known to induce uterus contraction, so, in the present study we have investigated the effect of aluminum chloride on uterine contractions induced by these three stimulants.
Method & Material: In this descriptive study the uterus of 24 mature virgin rat was removed from abdomen and mounted in an organ bath containing Tyrone solution (37˚C, 7.3-7.4 PH), bubbled with oxygen. Uterine contractility was recorded isometrically under 2g initial tension. After equilibrium period (60min), the percentage of changes in uterine contractility induced by KCl (1-5 mg/ml), oxytocin (0.001-100μg/ml) and acetylcholine (0.001-100 μg/ml) were recorded. The results were analyzed by using t-test and ANOVA statistical methods and P<0.05 was considered as significant.
Results: The results indicated that, KCl, OT and Ach enhance the uterine contractility. The uterus contractions induced by KCL, OT and Ach were also inhibited by aluminum chloride dose-dependently (P<0.0001).
Conclusion: From the obtained results we concluded that, aluminum chloride possibly inhibits KCl, oxytocin and acetylcholine stimulatory effect via blockade of the voltage dependent calcium channels.

 
Keyword(s): ALUMINUM, MUSCLE CONTRACTION, RATS, UTERUS, MUSCLE, SMOOTH
 
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