Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Fall 2003 , Volume 10 , Number 3; Page(s) 67 To 72.
 
Paper: 

A RARE CASE REPORT OF KIKUCHI'S DISEASE OR HISTIOCYTIC NECROTIZING LYMPHADENITIS

 
 
Author(s):  MAHMOUDI S.*, KERAMAT F., JAFARI M.
 
* Department of Surgery, School of Medicine, Hamadan University of Medical Sciences & Health Services , Hamadan , Iran
 
Abstract: 
Kikuchi's disease or histiocytic necrotizing lymphadenitis is uncommon disease that first time was recognized in Japan. The etiology of disease is unknown. Clinical features consist with unilateral cervical lymphadenopathy, often with upper respiratory prodrome and associated in some patients with fever. More cases occur in women, commonly under 40 years of age. The involved nodes are usually firm with rubbery, discrete and sometimes tender. Occasional patients present with generalized lymphadenopathy, and rarely, hepatosplenomegaly occurs. Diagnosis has been made by surgical biopsy & histological lymph node appearance.
The patient was a 27-years-old woman that was admitted in infectious ward of Sina Hospital in 2/1/2001. The patient had fever since 10 days and about 40 days she had a mass in her left cervical that grew gradually. In physical examination of patient showed erythema of pharynx, no exuda and a mass in left cervical area that was, nontender, rubbery , discrete with size 5×5 cm . Her temperature was 39.6°c. Initial diagnosis were Typhoid fever or Infectious mononucleosis. Laboratory tests were relative leucopenia (4000/mm3) with 48% lymphocytosis & 35% Atypical lymphocyte. She was admitted in hospital in date of 1/2/2001 with complients of fever, headache and vomiting. For the patient was performed surgical biopsy with initial diagnosis of lymphoma by specialist surgen. Pathologist was reported kikuchi's disease (histiocytic necrotizing lymphadenitis).
In the diagnositic approach to unilateral cervical lymphadenopathy and atypical lymphocytosis, kikuchi's disease despite of the other more common cause as lymphoma, infectous mononucleosis should be considered
 
Keyword(s): ATYPICAL LYMPHOCYTOSIS, HISTIOCYTIC NECROTIZING LYMPHADENITIS, LYMPHADENOPATHY
 
References: 
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