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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Fall 2003 , Volume 10 , Number 3; Page(s) 39 To 42.
 
Paper: 

COMPARISON OF INHIBITORY EFFECT OF GRIPE MIXTURE AND CARAWAY MIXTURE ON ACETYLCHOLINE INDUCED SPASM IN RAT JEJUNUM

 
 
Author(s):  ZERAATI F.*, MALAKOUTI S.M., ARAGHCHIAN M., SHEYKH NASRIN, NADI E.
 
* Department of Pharmacology, School of Medicine, Hamadan University of Medical Sciences & Health Services , Hamadan, Iran
 
Abstract: 

In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared.
2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 Co , 100% O2) . The jejunum was contracted because of acetylcholine (1 ml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test The results show that both drugs inhibit the spasm induced by acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The caraway mixture showed a higher effect in comparison with gripe mixture (P<0.05).
The caraway mixture has a higher inhibitory effect on acetylcholine induced spasm in rat jejunum . It seems that it has the same effect on human.

 
Keyword(s): ACETYLCHOLINE, PLANTS MEDICINAL, RATS, SPASM
 
References: 
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