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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   Spring 2004 , Volume 6 , Number 1(SN 21); Page(s) 0 To 0.
 
Paper: 

HIGH PREVALENCE OF CONGENITAL HYPOTHYROIDISM IN ISFAHAN, IRAN

 
 
Author(s):  HASHEMIPOUR MAHIN, AMINI MASOUD, JAVAHERI N., SATTARI G., HAGHIGHI S., HOVSEPIAN S., IRAN POUR R., JAVADI A.A., SADRI H.
 
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Abstract: 
Introduction: Hypothyroidism is one of the preventable causes of mental retardation, which according to its clinical manifestations within the neonatal period, can be diagnosed in only fewer than 10% of cases. Delayed diagnosis results in irreversible cerebro-auditory complications unless the problem is diagnosed by screening programs. Materials and Methods: From May to December 2002, T4 and TSH concentrations of 20,000 serum samples obtained from newborns on 3rd-7th day of birth, born in seventeen hospitals throughout Isfahan were measured by RIA and IRMA, respectively. The newborns with abnormal screening results (TSH> 20 mIU/L, T4<6.5 µg/dL and based on the weight) were re-examined. Newborns with TSH >10mIU/L and T4<6.5 µg/dL on the second measurement were considered to be hypothyroid so treatment was begun. After performing complementary tests, the hypothyroid patients received replacement therapy with levothyroxine. Results: From 20,000 neonates that were examined, 531 were recalled (Recall rate = 2.65%) and 54 newborns were diagnosed as hypothyroid. The prevalence of neonatal hypothyroidism was estimated to be 1/370. Conclusion: Considering the high prevalence of the disease in the population, the necessity of routine neonatal screening programs is underscored.
 
Keyword(s): CONGENITAL HYPOTHYROIDISM, SCREENING, T4, TSH
 
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