Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   June 2003 , Volume - , Number 55; Page(s) 29 To 39.
 
Paper: 

NUCLEOTIDE SEQUENCE OF GENE ENCODING CAPSID PROTEIN VP1 OF FOOT-AND-MOUTH DISEASE VIRUS/TYPE 0__1 IRAN

 
 
Author(s):  MASOUDI S.*, KHEDMATI K., PARVIN ASHTIANI M., KHORASANI A., SHAH SAVANDI SH., SADRI R.
 
* Poultry Vaccines Research & Production Dept, Razi Vaccine & Serum Research Institute,Tehran, Iran
 
Abstract: 

VP1 protein of foot-and-mouth disease virus (FMDV) contains the immunogenic hypervariable region of the virus. The antigenic variation in FMDV is particularly related to the difference between nucleotide and amino acid sequences of capsid protein. On the basis of this phenomenon, type diagnosis of FMDV can be done by the polymerase chain reaction (PCR). In order to specifically identify the O1 FMDV serotype of Iran the complete coding sequence of its VP1 protein was amplified by RT-PCR, and nucleotide and amino acid sequences of the PCR product were determined. The nucleotide and deduced amino acid sequence exhibited 84% and 88% homology with the VP1 region of serotype O1k, respectively.

 
Keyword(s): FOOT-AND-MOUTH DISEASE VIRUS, O1/IRAN, VP1, SEQUENCE, RT-PCR
 
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