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Paper Information

Journal:   MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2007 , Volume 29 , Number 2; Page(s) 87 To 93.
 
Paper: 

EFFECTS OF TRANSIENT AND PERMANENT INHIBITION OF THE AMYGDALA ON ACQUISITION OF PIRIFORM CORTEX KINDLED SEIZURES IN RATS

 
 
Author(s):  SHAHABI P., BABRI SH.*, SHAH SAVARI MAHBOUBEH
 
* PHYSIOLOGY LABORATORY, DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background and objectives: Epilepsy is one of the most common neuronal disorders in man. The amygdala is one of the important locations for seizures originated from piriform cortex. Neverthless, its role in development of such seizures has not been reported so far. Therefore in this study, the effects of amygdala inhibition on kindling rate of piriform cortex were investigated.

Materials and Methods: Under two study protocols, thirty male Wistar rats (300-350 g) in 5 groups (n=6) were studied. In the first protocol animals were divided into three groups; first group only were canulated without any treatment, second group received artificial CSF and third group received 0.5 ml of 2% lidocaine intra amygdaloid. The second protocol, included two groups; in the first group the amygdala was lesioned by electrical DC current and animals were stimulated 24 h later and in the second group animals canulated but amygdala was not lesioned

Results: In this study, intra amygdala injection of 2% lidocaine and electrical lesion of it increased number of stimulation to receive S4 and S5 stages of seizure, but had no effects on number of stimulations to receive S1, S2, S3 stages cumulative after discharge duration (ADD), after discharge threshold and ADD after the first duration.
Conclusion: We concluded that the amygdala has a critical role in the development of epileptic seizures from piriform cortex to other regions and this role is significantly affected by transient and permanent inhibition of neuronal activity of amygdala.

 
Keyword(s): SEIZURE, ELECTRICAL KINDLING, ELECTRICAL LESION, AMYGDALA
 
References: 
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