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Paper Information

Journal:   ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH   SUMMER 2007 , Volume 5 , Number 2 (SERIAL NUMBER18); Page(s) 1217 To 1221.
 
Paper: 

THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS

 
 
Author(s):  JALALI NADOUSHAN M.R.*, DAVATI A., GHARAH GOZ LOUEI M.
 
* SHAHED UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SOCIAL MEDICINE AND HEALTH
 
Abstract: 
Background: Breast cancer is the most common malignancy in women. Some biologic markers are used for determination of prognosis and prediction of treatment response. Cytokeratin 7 (CK7) is an Intermediate filament protein of epithelial cells. The purpose of this study is to determine the expression of cytokeratin 7 in primary breast cancer and it's correlation with grade, stage and axillary lymphnode involvement.
Materials and Methods: This was a cross-sectional study performed on 75 samples of patients with breast cancer admitted in Mostafa Khomeini Hosptial (2000-2005). After preparing the samples, a tissue section from each sample was obtained. One of the tumoral sections and one of the lymphnode sections were stained by H & E. We determined the type of the tumor, the number of lymphnodes, the stage and the grade of the tumor. We studied cytokeratin 7 with monocolonal antibady by IHC.
Results: Our study showed that 93.3% of samples were positive for cytokeratin 7. 70.7% of patients had lymphnod involvement, 57.3% of samples were in stage 11and the most of patients (42.7%) were in grade 11.In this study, we found significant relation between cytokeratin 7 and lymphnode involvement (P=0.002), lymphnode number (P=0.004) and stage (P=0.002). We didn't find any relationship between CK7 and grade.
Conclusion: According to he results of previous studies and our study, it seems that cytokeratin 7 is a prognostic factor in breast cancer. But further investigations with more specimens and long-time follow- p are required to clarify the exact role of cytokeratin 7 in prognosis of breast cancer.
 
Keyword(s): BREAST CANCER, CYTOKERATIN 7, GRADE, STAGE
 
References: 
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