Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   WINTER 2008 , Volume 25 , Number 87; Page(s) 77 To 88.
 
Paper: 

EFFECT OF VARICOCELECTOMY ON SEMEN PARAMETERS AND PROTAMINE DEFICIENCY 3 AND 6 MONTHS POST SURGERY

 
 
Author(s):  ASHRAFI S.*, NASRESFAHANI MOHAMMAD HOSSEIN, RAZAVI SH., ABBASI H., MOULAVI FARAHNAZ, TAVALAEI M.
 
* ROYAN INSTITUTE, ISFAHAN, IRAN
 
Abstract: 

Background: Different methods have been used to evaluate the beneficial effect of varicocelectomy; these include semen parameters and pregnancy rate.
Due to high biological variability of semen parameters, sperm functional tests have been considered as an efficient end point in assessment of fertility. Therefore, the aim of this study was to evaluate the effect of varicocelectomy on semen parameters and sperm protamine deficiency.
Methods: 3-4 days of abstinence used for semen analysis and assessment of sperm morphology, chromatin status using Chromomycin A3 and Papanicolaou staining respectively.
Findings: The results of present study show that all the 3 semen parameters and percentage of sperm with normal protamine content have improved post surgery (p<0.01).The cumulative pregnancy rate was 34.6%. The results reveal that mean sperm density, percentage of normal sperm morphology and acrosome were significantly higher in pregnant couples before surgery. However, by 6 months post surgery, sperm density and percentage normal morphology, normal sperm head and percentage of cytoplasmic droplet were significantly different between two groups. (p<0.05)
Conclusion: Therefore, the results of this study suggest that not only semen parameters but also normal protamine content, decrease cytoplasmic remnants and acrosome morphology which are index of sperm maturity increases following varicocelectomy. Furthermore, the results of present study reveals that patients with low initial sperm count may have a lower chance of pregnancy following varicocelectomy.

 
Keyword(s): VARICOCELE, VARICOCELECTOMY, SPERM CHROMATIN, FERTILITY, CYTOPLASMIC DROPLET, PROTAMINE DEFICIENCY
 
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