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Paper Information

Journal:   IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)   FEBRUARY 2008 , Volume 2 , Number 2; Page(s) 27 To 32.
 
Paper: 

USE OF A-INTERFERON, AMANTADIN ANDISOPRINOSINE IN SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE): COMPARING THE EFFECTIVENESS

 
 
Author(s):  NASIRIAN A.*, ASHRAFI M.R., EBRAHIMI NASRABADI S.
 
* CHILDREN'S MEDICAL CENTER
 
Abstract: 

Objective: Sub acute Sclerosing Pan Encephalitis (SSPE), a progressive neurological disorder characterized by inflammation of the brain (encephalitis), is the result of an inappropriate immune response to the measles virus or measles vaccination. SSPE usually develops 2 to 10 years after the original viral attack. Some of the major signs and symptoms are mental deterioration, jerky movements, and seizures specially myoclonic type, involuntary movements, and/or behavioral changes, difficulty in walking, speech, and loss of cognition, respiratory distress and death.
Materials and Methods: During the ten years, from July 1991 to July 2001, we admitted 45 cases of (SSPE), at different stages of the disorder. Regard less of their stage of disease, for intervention, randomly, we used one of three drugs; Amantadin, Interferon alfa and Isoprinosine, administered to the patients, for between one month to one year. Fourteen cases received Amantadin, 15Alfa interferon, and 16 were given Isoprinosine.
Results: While the results show all three drugs to be relatively effective, Isoprinosine showed four times more effectiveness than Amantadin and twice as much as Interferon.
Conclusion: The results showed Isoprinosine to be much more effective than Amantadin and Alfa interferon in treating the condition.

 
Keyword(s): SUB ACUTE SCLEROSING PANENCEPHALITIS, (SSPE), DAWSON'S DISEASE, SLOW VIRUS DISEASES
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

NASIRIAN, A., & ASHRAFI, M., & EBRAHIMI NASRABADI, S. (2008). USE OF A-INTERFERON, AMANTADIN ANDISOPRINOSINE IN SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE): COMPARING THE EFFECTIVENESS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 2(2), 27-32. https://www.sid.ir/en/journal/ViewPaper.aspx?id=106834



Vancouver: Copy

NASIRIAN A., ASHRAFI M.R., EBRAHIMI NASRABADI S.. USE OF A-INTERFERON, AMANTADIN ANDISOPRINOSINE IN SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE): COMPARING THE EFFECTIVENESS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN). 2008 [cited 2021July25];2(2):27-32. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=106834



IEEE: Copy

NASIRIAN, A., ASHRAFI, M., EBRAHIMI NASRABADI, S., 2008. USE OF A-INTERFERON, AMANTADIN ANDISOPRINOSINE IN SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE): COMPARING THE EFFECTIVENESS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), [online] 2(2), pp.27-32. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=106834.



 
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