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Paper Information

Journal:   JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES   WINTER 2008 , Volume 15 , Number 1; Page(s) 61 To 69.
 
Paper: 

DETERMINING OF METHAMPHETAMIN EFFECTS ON SPERM PARAMETERS OF MATURE RAT

 
 
Author(s):  TAGHAVI M.M.*, ALAVI S.H., MOALEM SEYED ADEL, VARASTEH A.A.R.
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Abstract: 

Introduction: Methamphetamine (MAMP) is a central nervous system stimulant, but it is increasingly abused as a psychedelic tablet by teenagers and young adults. In this experimental study, we evaluate the effects of MAMP on sperm parameters of mature rat.
Methods: MAMP or saline were injected in three experiments as follow: In the first experiment, twenty-four rats were injected one time with 10mg/kg MAMP, and sperms were sampled from tail of epididymis 6, 12, 24, 48, 72, and 168 h after injection (n=4, at each time). Six rats injected with saline served as controls. In the second experiment, four groups of rats each consisting of four rats were administered MAMP (5, 10 and 15mg/kg) or saline, respectively, and examined 24h later. In the third experiment, 16 rats were evenly divided into four groups (1, 5, and 10 mg/kg MAMP and control) and were injected MAMP or saline once daily for 14 consecutive days (spermatogenesis period) and sperms were sampled 24 h after the last injection.The motility, concentration and morphology of the sampled sperms were evaluated. We also measured the body and testis weights and used the testis/body weight ratio as an index at the end of each experiment.
Results: At 24 and 48 h after injection with a single dose of 10 mg/kg MAMP, the number of sperms decreased significantly in comparison with controls (p
£0.001 and P£0.05 respectively). In the second experiment, the number of sperms for three doses of MAMP significantly decreased in the two upper doses (P<0.001) and in the lower dose (P£0.05).The results of the third experiment were similar but the decrease of sperms number was more than that in the second experiment. MAMP did not change the testis/body weight ratio in the first and second experiments, but it significantly decreased this index in rats of the third experiment which received 10 and 5 mg/kg MAMP daily. We did not observe differences between experimental and control groups in motility and morphology of sperms.
Conclusion: Our results indicate that the repeated administration and/or higher doses of MAMP reduce the number of mature sperms in the tail of epididymis and have adverse effects on the reproduction and fertility of MAMP users.

 
Keyword(s): METHAMPHETAMINE, SPERM PARAMETERS, EPIDIDYMIS, RAT
 
References: 
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