Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   SUMMER 2007 , Volume 6 , Number 2 (23); Page(s) 101 To 108.
 
Paper: 

EFFECT OF GABAB AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT

 
 
Author(s):  REZVANIPOUR M.*, SHEYBANI VAHID, BAKHSHESH M.
 
* DEPT. OF PHYSIOLOGY, FACULTY OF MEDICINE, NEUROSCIENCE AND PHYSIOLOGY RESEARCH CENTER, UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Background and Objective: There are several evidences that show cuneiformis nucleus is involved in nociception. In the present study the effect of intra cuneiformis microinjection of GABAB agonist (baclofen) and antagonist (CGP35348) on morphine induced antinociception in rat were investigated.
Materials and Methods: In this expremental study, through canulation of cuneifoprmis nucleus in rat the effect of intra cuneiformis (CNF) microinjection of GABAB receptor agonist (baclofen) and antagonist (CGP35348) on morphine iduced antinociception were investigated by formalin test.
Results: Microinjection of morphine (10
mg /0.5 ml/saline) or different doses of baclofen (0.25, 0.5, 1 m/gper rat) had antinociception in the both first and second phases of formalin test. The response induced by morphine or baclofen in both phases were reduced by CGP35348. The responses induced by combination of baclofen (1mg per rat) and intraperitoneal (ip) injection of naloxan were reduced in both phases of formalin test. Microinjection of CGP35348 alone has produced antinociception in first phase of the formalin test. Morphine with different doses of baclofen did not increase the antinociception effect whereas microinjection of CGP35348 administration significantly increased the antinociception in acute phase.
Conclusion: It may be concluded that CNF GABAs receptor induced antinociception via opioid receptor in the formalin test.

 
Keyword(s): CUNEIFORMIS, CGP35348, BACLOFEN, GABAB, MORPHINE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 74
 
Latest on Blog
Enter SID Blog