Paper Information

Journal:   OLYMPIC   SUMMER 2008 , Volume 16 , Number 2 (SERIAL 42); Page(s) 75 To 86.
 
Paper: 

THE EFFECT OF CONTINUOUS AEROBIC EXERCISE ON THE RATE OF HSP70 IN MICE WITH BREAST CANCER TUMOR

 
 
Author(s):  AGHA ALINEZHAD HAMID*, TOUFIGHI ASGHAR, MOHAMMAD HASAN ZOHEYR, MAHDAVI MAHDI, SHAHROKHI S.
 
* PHYSICAL EDUCATION AND SPORT SCIENCE DEPT., TARBIAT MODARES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

This research was carried out to evaluate the effect of continuous aerobic exercise on the rate of HSP70 in mice with breast cancer tumor. For this aim 80 female balb/c mice were utilized and randomly divided in 4 groups as follow: 1. Exercise – Tumor – Exercise (ETE), 2. Exercise – Tumor – Rest (ETR), 3. Rest – Tumor – Exercise (RTE), and 4. Rest – Tumor – Rest (RTR). The effect of aerobic exercise on the rate of the HSP70 was evaluated before and after the tumor transplantation. Pre – tumor exercise regimen was done for 8 weeks at 50% to 75% Vo2max. Post – tumor exercise regimen was done for 4 weeks at approximately 60% Vo2max. The result of this research shows that the rate of HSP70 decreased in groups which after tumor transplantation participate in exercise programs (ETE and RTE groups). This reduction was seen in tumor volume and the amount of the survival rates in these groups too. Based on the results of this research HSP70 plays as a modulating signal in interaction with tumor and exercise. Therefore this proteins activity in normal conditions differs from which happens under stressful conditions. It seems that continuous aerobic exercise by reducing the HSP70 in tumor species, along with other procedures, can promote tumor treatment.

 
Keyword(s): BREAST CANCER, CONTINUES AEROBIC EXERCISE, FEMALE BALB/C MICE, HEAT SHOCK PROTEIN 70 (HSP70)
 
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