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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   WINTER 2008 , Volume 7 , Number 1; Page(s) 29 To 33.
 
Paper: 

SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF N-SUBSTITUTED IMIDAZOLE-5- CARBOXAMIDES IN FORCED SWIMMING TEST MODEL

 
 
Author(s):  HADI ZADEH F., HOSSEINZADEH HOSSEIN*, MOTAMED SHARIATI V.S., SEYFI MAHMOUD, KAZEMI SHAHAB
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, PHARMACY FACULTY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles, So, N-[(4-morpholinyl) ethyl)]-I-benzyl-2-(alkylthio)- IH-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activityusing forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively. 

 
Keyword(s): IMIDAZOLECARBOXAMIDES, MAOIS, ANTIDEPRESSANT, FORCED SWIMMING MODEL
 
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