Paper Information

Journal:   AMIRKABIR   FALL 2007- WINTER 2008 , Volume 18 , Number 67-E; Page(s) 59 To 68.
 
Paper: 

PREPARATION AND RELEASE BEHAVIOR EVALUATION OF H9N2 AVIAN INFLUENZA VIRUS LOADED PLGA MICROSPHERES USING DOUBLE EMULSION-SOLVENT EVAPORATION

 
 
Author(s):  KHAZEI J., OURANG F., NAZARI SHIRVAN A., AMINIAN M.
 
* 
 
Abstract: 

Microparticulate form of biodegradable polymers containing drugs is a promising approach toward new controlled release drug delivery systems, and a perfect alternative for daily painful injection of protein drugs. One major challenge in developing such systems is increasing efficiency of fabrication processes and retaining stability and effectiveness of encapsulated proteins and drugs. In this study capabilities of double emulsion (W/O/W)- solvent evaporation method for encapsulation of attenuated avian influenza virus (H9N2) in poly (lactic-co-glycolic acid) 50:50 were investigated and, the protein in vitro release profiles were determined. Some basic salts such as MgCo3 co-encapsulated with protein were used to increase stability and release of the protein. Additives such as NaCl and urea were added to second water phase to ensure and increase loading of the protein. The microspheres were all spherical with almost smooth surface and some small pores. Release profiles reveal that MgCo3 increased the amount of released protein but did not have a significant effect on release rate.

 
Keyword(s): CONTROLLED RELEASE DRUG DELIVERY SYSTEMS, BIODEGRADABLE POLYMERS, DOUBLE EMULSION-SOLVENT EVAPORATION METHOD, MICROSPHERE, POLY(LACTIC-CO-GLYCOLIC ACID), AVIAN INFLUENZA VIRUS (H9N2)
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 56
 
Latest on Blog
Enter SID Blog