Paper Information

Journal:   JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES   FALL 2007 , Volume 14 , Number 3 (32); Page(s) 36 To 41.
 
Paper: 

EFFECT OF LEVOTHYROXINE THERAPY ON THYROID PEROXIDASE ANTIBODY LEVEL IN 20-50 YEAR OLD FEMALES WITH HASHIMOTO’S DISEASE

 
 
Author(s):  KALBASI S.*, HOSSEINI HADI, NADI MOGHADAM S., SOLTANI MANSOUR
 
* DIABETES RESEARCH CENTRE, BIRJAND UNIVERSITY OF MEDICAL SCIENCES, BIRJAND, IRAN
 
Abstract: 

Background and Aim: Hashimoto's thyroiditis is the most prevalent cause of hypothyroidism in children and adults. The disease clinically manifests itself in three forms; namely hypothyroidism, euthyroidism, and hyperthyroidism. The present study was carried out aiming at determining anti-thyroid peroxidase antibody variation before and after levothyroxine treatment in hashimoto's thyroiditis patients.
Materials and Methods: In this quasi-experimental study, at first patients with firm goiter referring to Birjand glands deficiency clinic between 2005 and 2006 were examined and those with positive anti- TPO antibody were accounted as hashimoto cases. Then, these cases were prescribed a three- month treatment with 100 microgram daily of levothyroxine. At the end of the period, their level of anti- TPO antibody was measured and their clinical conditions were assessed. The obtained data was then analysed by means of SPSS software; statistical tests including independent t, paired t test and chi-square test.
Results: Majority (67.1%) of the patients was diagnosed as hypothyroid, and 32.9% were euthyroid cases. The level of anti-TPO antibody in 20% of the patients reached normal level after a period of three month treatment with levothyroxine. Mean anti-TPO antibody level before levothyroxine treatment was 450.74
±122.05 IU/mL, which reduced to 236.2±153.96 IU/mL after treatment (P<0.001). Mean anti-TPO antibody level before treatment was higher (P<0.001) in hypothyroid patients compared with euthyroid ones. After treatment with levothyroxine, antibody level in hypothyroid cases also remained higher than that of euthyroid ones (P<0.001).
Conclusion: Anti-TPO antibody level in Hashimoto patients with hypothyroidism is higher than euthyroid ones. After treatment, anti-TPO antibody level decreases in both groups but the decrease is more prominent in euthyroid cases than patients who remain hypothyroid. Regarding these facts, it could be confirmed that anti-TPO antibody measurement (as an important diagnostic and follow-up procedure and for prognosis in Hashimoto) will be useful.

 
Keyword(s): THYROIDITIS, HASHIMOTO, ANTI-THYROID PEROXIDASE (ANTI-TPO), HYPOTHYROIDISM, EUTHYROIDISM
 
References: 
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