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Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   WINTER 2007 , Volume 28 , Number 56; Page(s) 47 To 55.
 
Paper: 

SECOND DOSE OF THIOPENTAL IS COMPARABLE WITH LIDOCAINE FOR ATTENUATING THE CARDIOVASCULAR RESPONSE TO ENDOTRACHEAL INTUBATION

 
 
Author(s):  SAFAVI M.R., HONARMAND AZIM
 
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Abstract: 

Background: The study undertaken to compare the effectiveness of second dose of thiopental with intravenous lidocaine on the hemodynamic response to laryngoscopy and intubation.
Materials and Methods: 120 patients aged between 15 to 65 years were enrolled to this study in four divided groups (n= 30 each group). Patients in each group were given 2
mg/kg fentanyl IV, 4mg/kg thiopental for induction of anaesthesia, then 0.5 mg/kg atracurium for muscle relaxation and a second dose of thiopental (1 mg/kg in group 1,2mg/kg in group 11) just before laryngoscopy and intubation, lidocaine 1.5mg/kg (group III) or normal saline 5 ml (group IV) and 2 mins later laryngoscopy and intubation. The heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (OAP), mean arterial pressure (MAP), and rate pressure product (RPP) were measured before induction of anaesthesia (baseline), before laryngoscopy (BL), at 1, 3, 5, and 10 mins after laryngoscopy and intubation (T1, T3, T5, T10 respectively).
Results: Our results showed that comparable with lidocaine second dose thiopental attenuated increase in OAP, SAP and MAP, RPP and HRtill 1 min, 3 min, and 5 min and after endotracheal intubation (El) respectively. Changes in hemodynamic variables after El from the baseline values showed that comparable with lidocaine, the second dose thiopental 2 mg/kg significantly decreased SAP, MAP, and RPP changes till3 min after El. Compared with placebo, HR changes were significantly reduced after the second dose thiopental 2 mg/kg till 5 min after El.
Conclusions: Second dose thiopental can be used as an alternative to lidocaine in attenuation of cardiovascular response to intubation in patients without ischemic heart disease.
 

 
Keyword(s): THIOPENTAL, LIDOCAINE, INTUBATION, CARDIOVASCULAR RESPONSE
 
References: 
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