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Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   WINTER 2007 , Volume 28 , Number 56; Page(s) 34 To 39.
 
Paper: 

THE EVALUATION OF THE EFFECT OF REMIFENTANIL ON BLOOD PRESSURE AND HEART RATE OF MOTHERS SIND NEONATE'S APGAR SCORE, DURING INDUCTION OF GENERAL ANESTHESIA IN ELECTIVE CESAREAN SECTION

 
 
Author(s):  KARBAS FROUSHAN A., CHOUBSAZ M., SAD ALDIN GH.R.
 
* 
 
Abstract: 

Background: Restricted use of opioids is one of the problems in elective cesarean section surgery, because it may cause fetus complications such as central nervous system and respiratory system depression in neonates. Nevertheless, disuse of opioids in cesarean may endanger the mothers. Using new short acting opioids, such problem might not be confronted. This study was performed to evaluate the effect of remifentanil on maternal blood pressure, heart rate and neonatal APGAR score during induction of general anesthesia in elective cesarean section surgery.
Materials and Methods: This study is a double blinded randomized clinical trial. 44, 18-35 years old women candidated for elective cesarean section surgery in Motazedi Hospital were put in two equal randomized groups. Remifentanil was infused in dose of 0.5
mg/ Kg/min of a 25 mg/mL solution in case group one minute before thiopental injection untill one minute after intubation. Normal saline was infused in control group at the volume of 0.02 mL/kg. Total infusion time in both groups was 3 minutes. Maternal blood pressure and heart rate were measured before induction (one minute before intubation) and one minute after intubation in both groups. APGAR score was measured 1 minute, 5 minutes and 20 minutes after birth in neonates in both groups.
Results: Comparison of the mean systolic blood pressure changes before and after induction of anesthesia showed significant difference between case and control group (case group: 0.59
±7.3 mmHg; control group 23.5±8.4 mmHg, p<0.001). Mean mothers heart rate changes before and after induction, also showed significant difference between cases and control (case group: 1.6±5.4 beat/min; control group 19.3±10 beat/min, p<0.05).
The first and the fifth minute APGAR score did not show any significant difference between these groups. Conclusion: According to the findings of this study, it seems that remifentanil can prevent maternal hemodynamic changes during cesarean section surgery and does not reduce neonates APGAR score comparing with those whose mothers haven't taken remifentanil.
By more research studies and similar findings remifentanil might be allowed to administer for induction of cesarean section surgery.

 
Keyword(s): CESAREAN SECTION SURGERY, REMIFENTANIL, HEART RATE, BLOOD PRESSURE, APGAR
 
References: 
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