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Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   WINTER 2007 , Volume 28 , Number 56; Page(s) 12 To 18.
 
Paper: 

ANALGESIC AND SEDATIVE EFFECTS OF CLONIDINE IN BUM PATIENTS

 
 
Author(s):  OSTAD ALIPOUR A., JAMSHIDI MOZHGHAN, JAMSHIDI MARYAM, ZAMANI KIASARI ALIEH, TAVASOULI ASHRAFI AHMAD, MAGHSOUDLOU MAZIYAR, ROKHSARI FARIDEH
 
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Abstract: 

Background: Non opioid treatments for pain after therapeutic procedures on patients with burns have become popular because of the side effects associated with narcotics. The aim of this study was to evaluate the analgesic and sedative effects of clonidine, an a2 adrenoceptor agonist in burn patients.
Materials and Methods: In this randomized, double-blind, placebo-controlled clinical trial 100 burn patients were divided in two groups. Case group (n=50) received oral clonidine, 3.3
mg/kg TDS and controls (n=50) received placebo. Pain severity (VAS), heart rate and systolic blood pressure were recorded after clonidine administration. Statistical analysis was done by means of analysis variance, Chi-square and T-test.
Results: 50 patients (mean age 28.96
±10 years) in case group, and 50 patients (mean age 27.60±11.4 years) in control group were studied. VAS pain scores and heart rate in the clonidine group were significantly lower than control group (p<0.0001, p<0.02). There was no significant difference in systolic blood pressure between two groups in first and second day but in third day the systolic blood pressure in clonidine group was lower than controls significantly (p=0.002).
Conclusion: This study demonstrates that the topical use of oral clonidine affects the hemodynamic response to pain in burn patients.

 
Keyword(s): CLONIDINE, ANALGESIA, SEDATION, BURNS
 
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