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Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   WINTER 2007 , Volume 28 , Number 56; Page(s) 5 To 11.
 
Paper: 

EVALUATION OF ECG AND APACHE II SCORE IN TRICYCLIC ANTIDEPRESSANT POISONING

 
 
Author(s):  IZADI MOUD NASTARAN, GHESHLAGHI F., JARGOUEI M.R.
 
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Abstract: 

Backgrounds: Tricyclic antidepressants (TCA) poisoning is the most common cause of drug poisoning in Poisoning Emergency Department of Noor Hospital, Isfahan, Iran. TCAs poisoning can nervous system and cardiovascular toxicity, the latter being responsible for the mortality. The ECG is a simple readily available diagnostic test that can predict the development' of significant toxicity. The objective of this study was to compare APACHE Score with ECG abnormalities in predicting the complications of toxicity in TCAs poisoned patients.
Materials and Methods: This study was a descriptive-analytic and prospective cohort. 84 TCAs poisoned patients were evaluated in Poisoning Emergency Department of Noor Hospital Isfahan, Iran.
After taking history and physical examination, ECG and other lab tests were performed. The APACHE 11 score was also determined for all patients. SPSS software, using paired student Hest and Chi-square test analyzed the data.
Results: There was a significant relationship between ECG abnormality and APACHE 11 score (p-value<0.001). APACHE 11 score mean in-patients with normal and abnormal ECG were 1.76
±1.4B, and 5.93±3.15 respectively. There was also a significant relationship between APACHE Score with prognosis (p-value<0.001). The mean of APACHE Score in the patients with poor prognosis (arrhythmia. hypotention, seizure and mortality) was 5.95±0.48 and in patients with good prognosis was 1.73±0.22.
Conclusion: APACHE 11 score can be used as a useful method for prediction of severity of toxicity.

 
Keyword(s): TRICYCLIC ANTIDEPRESSANTS, ELECTROCARDIOGRAM, APACHE II SCORE, POISONING
 
References: 
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