Paper Information

Journal:   JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)   WINTER 2008 , Volume 17 , Number 66/1 (BIOLOGY ISSUE); Page(s) 95 To 100.
 
Paper: 

THE EFFECT OF INVIRONMENTAL FACTORS ON THE ACTIVITIES OF QUINOLONES AND FLOUROQUINOLONES AGAINST COLIFORMS

 
 
Author(s):  GHAVAM ZADEH H.*, MALEKZADEH F., AKHAVAN SEPAHI A.
 
* BIOLOGY DEPARTMENT, NORTH TEHRAN BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

In contrast to our wealth of knowledge on the antibiograms, there is a relative paucity of knowledge on the impact of different chemotherapeutics under various conditions.
Commercially available fluoroquinolones are relatively new synthetic therapeutic agents which are used against g+, g- and anaerobic bacterial infections. In this study, the effect of the selected parameters such as temperature, pH, Ca+2,Na+, Mn+2, Fe+2 and Zn+ cations on the activity of nalidixic acid, ciprofloxacin, o floxacin and enrofloxacin against coliform bacteria were investigated by using broth dilution method in Muller-Hinton medium. The results obtained, revealed that, temperature 25-35
°C resulted in reduced activities of quinolones and fluoroquinolones. While temperature 40°C, increased the efficiency of these agents. Acidic pH (up to 5.5), increased the activities of quinolones and decreased the activities of fluoroquinolones against bacteria. Whereas alkaline H, (up to 8.5), show opposite impacts. NaCl, up to concentrations 250 mg/ml, have no significant effects on the activities of these agents. Addition of CaCl2, FeSo4 and MnS04, up to 250 mg/ml, decreased the activities of the agents. Adding of 100 mg/mlof ZnCl2, to the medium has little effect on the activities of these agents. It seemed the activities of the therapeutic substances used, varied under various environmental parameters. In each case, one must find optimum conditions of the agents used in vivo, in order to have the most effective against infections.

 
Keyword(s): QUINOLONE, COLIFORM, ENVIRONMENTAL PARAMETRS
 
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