Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)   WINTER 2008 , Volume 17 , Number 66/1 (BIOLOGY ISSUE); Page(s) 11 To 24.
 
Paper: 

EFFECT OF TESTOSTERONE ENANTHATE ON ACQUISITION MORPHINE –INDUCED CONDITIONED PLACE PREFERENCE; USING BRAIN MICRODIALYSIS IN ADULT MALE RAT

 
 
Author(s):  HEYDARIEH N.*, ORYAN SHAHRBANOU, VAHAB ZADEH A.A.V., BABAPOUR V., HAERI ROUHANI SEYED ALI
 
* BIOLOGY DEPARTMENT, SCIENCE FACULTY, ISLAMIC AZAD UNIVERSITY, RESEARCH & SCIENCE CAMPUS, TEHRAN, IRAN
 
Abstract: 
Tolerance and dependency are two main problems of drug abuse including morphine administration. It has been suggested that many drugs are involved in morphine induced psychological dependency. The current study was aimed to determine that, weather or not long-term intracerebroventricular (ICV) perfusion of testosterone enanthat could modify the acquisition of morphine-induced conditioned place preference (CPP) in adult male wistar rat.
Male wistar rats (250-300gr) were anaesthetized with chloral hydrate (500 mg/kg, i.p.). Guide cannula was implanted in the right lateral ventricle using stereotaxic instrument. After one week recovery from surgery, rats subjected to subcutaneous administration of morphine, and long-term ICV perfusion of testosterone enanthat (21
mmin for 2 hours) using microdialysis probe and guide cannula. Biased method was used to determine the induction of Cpp in rats. Changes were monitored in all groups;and all statistical analysis were carried out using absolute data and one-way ANOVA.
The present results indicated that subcutaneous of different doses of morphine sulfate (0.5- 10 mg/kg) produced a significant dose-dependent CPP in all experimental groups. The ICV perfusion of testosterone enanthate (2mg/kg) did not produce reliable CPP, however, longterm ICV perfusion of testosterone enanthate significantly modified the acquisition of morphine-induced (10mg/kg) conditioned place preference.
Data from the present investigation suggest that testosterone enanthate influence morphine dependent euphoria and /or reward.
 
Keyword(s): TESTOSTERONE ENANTHATE, MORPHINE, ACQUISITION CONDITIONED PLACE PREFERENCE, PSYCHOLOGICAL DEPENDENCY, MICRODIALYSIS
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 73
 
Latest on Blog
Enter SID Blog