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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MAY 2008 , Volume 11 , Number 3; Page(s) 318 To 321.
 
Paper: 

THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION

 
DOI: 

08113/AIM.0014

 
Author(s):  AHMADI SEYED ALI*, BOROUMAND M.A., GOUHARI MOGHADAM K., TAJIK PARVIN, DIBAJ S.M.
 
* DEPARTMENT OF PATHOLOGY, SINA HOSPITAL, TEHRAN, IRAN
 
Abstract: 

Most clinical laboratories directly measure serum triglyceride, total cholesterol, and highdensity lipoprotein cholesterol. They indirectly calculate low-density lipoprotein cholesterol value using the Friedewald equation. Although high serum triglyceride (>400 mg/dL or 4.52 mmol/L) devaluates low- density lipoprotein cholesterol calculation by using this formula, effects of low serum triglyceride (<100 mg/dL or 1.13 mmol/L) on its accuracy is less defined.
Two hundred thirty serum samples were assayed during a one-year period. In 115 samples, the triglyceride level was below 100 mg/dL and in 115 samples from age- and sex-matched patients the triglyceride level was 150 – 350 mg/dL (1.69 – 3.95 mmol/L). In both groups total cholesterol was above 250 mg/dL (6.46 mmol/L). On each sample, total cholesterol, high-density lipoprotein cholesterol, and triglyceride were directly measured in duplicate and low-density lipoprotein cholesterol measured directly and calculated with Friedewald equation as well.
Statistical analysis showed that when triglyceride is <100 mg/dL, calculated low- density lipoprotein cholesterol is significantly overestimated (average :12.17 mg/dL or 0.31 mmol/L), where as when triglyceride is between 150 and 300 mg/dL no significant difference between calculated and measured low-density lipoprotein cholesterol is observed.
In patients with low serum triglyceride and undesirably high total cholesterol levels, Friedewald equation may overestimate low-density lipoprotein cholesterol concentration and it should be either directly assayed or be calculated by a modified Friedewald equation. Using linear regression modeling, we propose a modified equation.

 
Keyword(s): CHOLESTEROL, HDL, LDL, TRIGLYCERIDE
 
References: 
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