Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MAY 2008 , Volume 11 , Number 3; Page(s) 286 To 292.
 
Paper: 

EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST

 
DOI: 

08113/AIM.0010

 
Author(s):  FAZLI TABAEI S., MAGHSOUDI A., BAZAZ A., BAZAZ N., MODIRZADEH A., ZARINDAST M.R.*
 
* DEPARTMENT OF PHARMACOLOGY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background: In the present study, the effect of dextromethorphan on antinociception and tolerance induced by water swim-stress in the formalin test was investigated.
Methods: Swim- stress at 80C induces antinociception in both phases of the formalin test.
Intraperitoneal administration of dextromethorphan (60 mg/kg) also induces antinociception in the second phase of the formalin test. The lower doses of dextromethorphan (1.25, 2.5, and 5 mg/kg) which did not induce antinociception alone, but did so in combination with swim- stress (40 second), showed antinociceptive effect in both phases of the test. Exposure to water swimming stress with a period of 20 sec, once daily for three days, altered swim- stress- induced antinociception in the formalin test, when tested on the fourth day.
Results: In these animals, exposure to either water swimming stress alone or water swimming stress in combination with dextromethorphan showed potentiation of antinociception induced by swim- stress up to 20 second and decreased the response induced by 40 and 60 second swimstress, indicating a tolerance induction. Dextromethorphan (20 mg/kg) did not alter the changes induced by three days exposure to swim- stress.
Conclusion: The results may indicate a possible involvement of n-methyl-d-aspartate receptor mechanism in the antinociception but not tolerance induced by swim- stress at 8
°C.

 
Keyword(s): DEXTROMETHORPHAN, FORMALIN TEST, MICE, SWIM-STRESS-INDUCED ANTINOCICEPTION, TOLERANCE
 
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