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Paper Information

Journal:   IRANIAN JOURNAL OF BIOLOGY   WINTER 2008 , Volume 20 , Number 4; Page(s) 438 To 446.
 
Paper: 

THE EFFECT OF INTRA NUCLEUS ACCUMBENS SHELL INJECTION OF RETINOIC ACID ON FOODINTAKE AND BODY WEIGHT IN RATS

 
 
Author(s):  SHOJAEI NARGES, ABBASNEZHAD MAHDI*, POURABOULI IRAN
 
* DEPT. OF BIOLOGY, FACULTY OF SCIENCES, SHAHEED BAHONAR UNIVERSITY, KERMAN, I.R. OF IRAN
 
Abstract: 

Retinoids are lipophilic compounds derived from vitamin A that affect many metabolic and developmental processes. They do physiological and pharmacological functions by regulating transcription of specific target genes. As we know central nervous system controls foodintake and body weight through hypothalamus. Nucleus accumbens also regulate foodintake, body weight and metabolism by connection with hypothalamus. In this study we investigated the effect of retinoic acid (RA) microinjection into Nucleus accumbens shell on body weight and foodintake. Rats were anaesthetized with ketamin- xylazine (60mg/kg - 4mg/kg,i.p) and cannulae were implanted bilaterally in the nucleus accumbens shell (AP=1.7mm from bregma, LA=0.8mm, DM=5.6mm from scale). After recovery period retinoic acid (1.5 ,3 ,6 mg/Rat) were injected daily (volum 0.5ml) for 4 successive days and body weight and foodintake were measured daily. The results showed that centrally injected retinoic acid in nucleus accumbens didn’t affect food intake but decreased body weight significantly. It shows relationship between nucleus accumbens and hypothalamic area that regulate foodintake and body weight. Therfore RA can change foodintake and body weight via the nucleus accumbens shell.

 
Keyword(s): RETINOIC ACID (RA), FOODINTAKE, BODY WEIGHT, NUCLEUS ACCUMBENS
 
References: 
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