Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF BIOLOGY   WINTER 2008 , Volume 20 , Number 4; Page(s) 430 To 437.
 
Paper: 

STUDY INTERACTION BETWEEN OXYTOCIN AND (ALPHA)2 – ADRENOCEPTORS IN LOCUS CORELEUS ON HEIGHT INDUCED ANXIETY IN MALE RAT

 
 
Author(s):  ZAL KHANI SAKINEH*, KESMATI MAHNAZ, ZANGANEH FARIDEH, RASEKH A.A.R.
 
* BIOLOGY DEPT., FACULTY OF SIENCE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, I.R. OF IRAN
 
Abstract: 

Some studies have shown that oxytocin affects many physiological phenomena via the central nervous system with unknown mechanisms. In the present study the effect of oxytocin administration in locus coeruleus and its interaction with α2 adrenoceptors antagonist on anxiety behavior in male rats was investigated. The wistar adult male rats weighing 285±15 grams were divided in five groups: Receiving saline, oxytocin (2ng/2ml), yohimbine (3.3mg/2ml), yohimbine + oxytocin, saline + oxytocin in locus coeruleus nucleus. The anxiety behavior evaluated with elevated plus maze. Results indicated that oxytocin increased anxiety in elevated plus maze but no effect in locomotors activity. Yohimbine as a a2 receptors antagonist in locus coeruleus increased anxiety and did not affect locomotors activity. Anxiogenic effect of oxytocin in presence of yohimbine increased but did not change locomotors activity. These results suggested that oxytocin may influences neural factors in locus coeruleus nucleus and probably changes anxiety parameters via a2 – adrenoceptors system.

 
Keyword(s): OXYTOCIN, YOHIMBINE, LOCUS COERULEUS, ANXIETY, ELEVATED PLUS MAZE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 85
 
Latest on Blog
Enter SID Blog