Paper Information

Journal:   IRANIAN JOURNAL OF BIOLOGY   WINTER 2008 , Volume 20 , Number 4; Page(s) 383 To 390.
 
Paper: 

ENHANCEMENT OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS IN THE MEDIA CONTAINING LOW-LEVEL CONCENTRATION OF VEGETABLE OILS

 
 
Author(s):  HAMEDI J.*, SALEHI NAJAF ABADI A., TIR ANDAZ H.
 
* DEPT. OF MICROBIOLOGY, SCHOOL OF BIOLOGY, UNIVERSITY COLLEGE OF SCIENCE, TEHRAN UNIVERSITY, TEHRAN, I.R. OF IRAN
 
Abstract: 

Clavulanic acid is a Beta-lactam antibiotic produced by Streptomyces clavuligerus. In this investigation, effect of rapeseed oil and soybean oil on the antibiotic production was studied. The amount of 0.1 – 20 g/l of the oils was supplemented to the basal fermentation media, which were containing malt (medium 1) and malt + dextrin (medium 2) as carbon sources. Maximum concentration of clavulanic acid was obtained in the media supplemented by 0.25 g/l rapeseed oil and 0.5 g/l soya oil. Enhancing effect of the oils was seen in the media containing up to 1 g/l of the oils. However, concentration of clavulanic acid was decreased in the media containing more than 1 g/l of the oils.

 
Keyword(s): ANTIBIOTIC, CLAVULANIC ACID, RAPESEED OIL, SOYBEAN OIL, STREPTOMYCES CLAVULIGERUS
 
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