Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS   2008 , Volume 2 , Number 2; Page(s) 0 To 0.
 
Paper: 

DOES TGF BETA SUPPRESSING EFFECT OF SIMVASTATIN LEAD TO PROTECTION AGAINST SURGICAL ADHESION BAND FORMATION?

 
 
Author(s):  GHARIBZADEH SHAHRIAR, HOSSEINI S.SH.*
 
* FACULTY OF MEDICINE, MEDICAL SCIENCE/TEHRAN UNIVERSITY, TEHRAN, IRAN QODS DORMITORY (NO. 54), SHAHED ALLEY, QODS STREET, TEHRAN, IRAN
 
Abstract: 

Intra-abdominal adhesions are the most common cause of small bowel obstruction. Infertility in women and chronic abdominal-pelvic pain are the other problems of adhesiogenesis which impose a great economic burden on the population health. On the other hand, increased levels of transforming growth factor beta1 (TGF-b) are shown to play a role in formation of adhesion bands and can impair peritoneal fibrinolysis. Moreover, simvastatin, an immunomodulator agent, can down-regulate TGF-b. Although it is shown in previous studies that simvastatin antagonizes the interaction between TGF-b and connective tissue growth factor (CTGF), no human study exists on the effect of simvastatin on surgical adhesion band formation. We hypothesize that simvastatin, through its effect on reducing the level of TGF-b, may be useful in preventing adhesion band formation after surgical procedures. Surely, this hypothesis should be assessed in several experimental and clinical trials.

 
Keyword(s): SIMVASTATIN, INTRA ABDOMINAL ADHESION BANDS, BOWEL OBSTRUCTION, TRANSFORMING GROWTH FACTOR BETA
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 60
 
Latest on Blog
Enter SID Blog