Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS   2008 , Volume 2 , Number 2; Page(s) 0 To 0.
 
Paper: 

DIABETES FOOT ULCERS: A NOVEL TREATMENT STRATEGY

 
 
Author(s):  KALAVI KH.*, MORADI A.A.V., KESHTKAR A.A., KALAVI M., NAMAZI G., MOHAGHEGH HAZRATI S.
 
* GOLESTAN UNIVERSITY OF MEDICAL SCIENCES AND GOLESTAN RESEARCH CENTER OF GASTROENTEROLOGY & HEPATOLOGY (GRCGH)
 
Abstract: 

Foot ulcers are common in 12-25 percent of diabetic patients. Preventing, controlling and treating of these kind chronic wounds are of the major clinical challenges. Evidence based documents revealed that DFU (Diabetic Foot ulcer) is a chronic wound type originating from disturbed cellular and molecular mechanisms that have to be in its functional form to overcome its problem. In diabetes and some other chronic based diseases, harmonized acting machine causes chronic phases that result in conditions as foot ulceration and related complications seen commonly in diabetes. DFU needs to be transformed into acute phase in order to be healed in a physiological manner. Disturbed mechanisms have to be corrected reversely and to achieve such a goal it is essential to better understanding of disturbing factors responsible for biological abnormalities. Factors associated with DFU are as cellular and molecular recruitment and function impairments and there is need to repair these mechanisms. For this, we believe that the activated Th-1 cells (T helper-1 Cells) might have a critical role in regulation of the several effector functions of the cellular and molecular mechanisms essential to the body to act the best. Evidences and our successful results urge us to suggest this regulatory role for effector cells and molecules generated through activation of Th-1 cells as a treatment strategy.

 
Keyword(s): DIABETIC FOOT ULCER, TREATMENT, ACTIVATION, TH-1 CELLS
 
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