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Paper Information

Journal:   JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES   FALL 2007 , Volume 16 , Number 63; Page(s) 1 To 10.
 
Paper: 

THE ROLE OF NITRIC OXIDE SYNTASE ENZYME INHIBITOR ON ANTIARRHYTHMIC EFFECTS OF CROCUS SATIVUS ON ISOLATED RABBIT ATRIOVENTRICULAR NODE

 
 
Author(s):  KHOURI V., NAYEBPOUR M., RAKHSHAN E., MIRABBASI A.
 
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Abstract: 

Introduction: Nitric oxide, directly or indirectly, can modulate electrophysiological parameters of the heart. On the other hand Nitric Oxide Syntase enzymes were founded in the Av-node. Various studies pointed to Anti ischemic and Hypotensive effects of the Crocus Sativus (Saffron).

Objective: To determine the effects of Hydroalcholic extract of Saffron on the tonic and functional properties of Atrioventricular Node and the role of Nitic Oxide in the mechanism of Saffron.

Materials and Methods: In this experimental study, We used isolated Newlands male rabbits with the method of isolated perfused AV-node in the suitable experimental condition, in three separate groups, in the first group (N=20), we assessed effect of hydroalcoholic extract of Crocus Sativus (19x10-2 mg/l) in order to survey its Electrophysiological effects on AV-node (before and after). In the second group (N=6) Saffron in presence of LName (75mmol) and in the third group (N=6) Verapamil (0/1mmol ) were examined. The primary characteristics are including: Nodal Conduction Time (AVCT), Wenckebach Time (WBCL), Effective & Functional Refractory Period(ERP&FRP). All changes in the variables were detected on line by A/D board and Av node pack software.

Results: The results have shown an inhibitory effects of Crocus Sativus on basic (AVCT, WBCL, FRP) and Functional Electrophysiological Parameters of AV -node including an increasing AVCT (32.4±4 to 41.7±4 msec) and FRP (157.6±3 to 163.7±4 msec). Also we had significant increased in the amount of facilitation and magnitude of fatigue (5.9±0.3 to 11.1±1 msec). NOS inhibitor (L-Name) has preventing effect on depressant effect of Crocus Sativus on AVCT and FRP.

Conclusion: The hydroalcholic extract of Crocus Sativus can use as Anti -Arrhythmic drug by increasing (AVCT) and (FRP). A part of its effects mediated by Nitrigic pathway.

 
Keyword(s): ARRHYTHMIA, NITRIC OXIDE, SAFFRON, ATRIOVENTRICULAR NODE
 
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