Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   AUGUST-SEPTEMBER 2007 , Volume 9 , Number 3 (38); Page(s) 39 To 42.
 
Paper: 

COMPARISON OF ATROPINE-PROMETHAZINE COMBINATION AND PETHIDINE EFFECTS ON ACTIVE PHASE OF LABOR

 
 
Author(s):  SAAT SAZ S.*, HAJI AHMADI M., BASIRAT Z., NAZARI ROGHAYEH, BEHESHTI Z.
 
* AMOL MIDWIFERY & NURSING FACULTY
 
Abstract: 

BACKGROUND AND OBJECTIVE: Since normal vaginl delivery and encouraging women to undertake vaginal delivery and the importance of reducing the duration of labor are known, this study was performed on nulliparous women who referred to Emam Ali hospital in Amol.
METHODS: This single blinded clinical trial was performed on two experimental and one control groups (60 patients in each group). At the beginning of the active phase of labor (4cm dilation), combination of atropine-promethazine (0.5 mg atropine- 25mg promethazine) and pethidine (50 mg), and 2 milliliter normal saline injected intramuscularly to experimental groups and control group, respectively. Then duration of the active phase of labor was evaluated with vaginal examinations. Women with history of preterm labor, preterm rupture of membrane, preeclampsia, twin pregnancy, abnormal presentation, pelvic contraction, induction of labor and any other chronic diseases were excluded from this study.
FINDINGS: One hundred and eighty nulliparous women aged 15-35 years were studied. The duration of active phase of labor was 185.6
±69.1 minutes in atropine-promethazine group, 228.9±105.5 minutes in pethidine group and 245.9±90.1 minutes in control group which showed statistically significant differences (p=0.001) but no significant difference was found between pethidine and control groups (p<0.063).
CONCLUSION:  Considering the effect of atropine-promethazine combination in reducing the duration of active phase of labor, its administration is recommended during labor.

 
Keyword(s): ATROPINE, PROMETHAZINE, PETHIDINE, ACTIVE PHASE DURATION
 
References: 
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