Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   AUGUST-SEPTEMBER 2007 , Volume 9 , Number 3 (38); Page(s) 20 To 26.
 
Paper: 

COMPARISON OF BASAL HORMONAL LEVELS IN PATIENTS WITH EXPLAINED AND UNEXPLAINED CAUSES OF RECURRENT ABORTION

 
 
Author(s):  BASIRAT Z.*, HAJIAN K., BASIRAT FATEMEH
 
* BABOL UNIV. MEDICAL SCIENCES
 
Abstract: 

BACKGROUND AND OBJECTIVE: Recurrent miscarriage is defined as at least two consecutive pregnancy losses during first trimester. Spontaneous pregnancy is dependent to endocrinologic changes of the menstrual cycle that may be effect on pregnancy outcome. This study was designed to investigate possible relation between hormonal changes with recurrent miscarriages.
METHODS: A total of 92 women with a history of recurrent miscarriage attending in Fatemeh Zahra infertility center were evaluated with hysterosalpingography, parental karyotype, vaginal sonography, immunologic tests, past history and physical examination. Following investigation, 57 women failed to reveal an identifiable cause, and were therefore classified as having unexplained recurrent pregnancy loss. The control group consisted of women with known cause of abortion. Hormone levels (LH, FSH, TSH and prolactin) compared between two groups. Data were analyzed using Fisher’s exact test and t-test.
FINDINGS: Of the 92 women included in this study, 35 had an identifiable cause. The median age was 29.2
±6.5 (18-41 years), the median number of miscarriage was 2.8±1.1 and the median duration of marriage was 5.5±4.2 (1-20 years). TSH serum concentration was significantly lower in unexplained group (p=0.004) (2.3±1.8 and 1.5±1, respectively), and prolactin concentration was higher in PCO patients (p=0.05).
CONCLUSION: The results showed an increased rate of prolactin in PCO patients with recurrent miscarriage and a decreased rate of TSH in unexplained recurrent miscarriage. It is possible that these disturbances may be causally related to miscarriage.

 
Keyword(s): RECURRENT ABORTION, RECURRENT PREGNANCY LOSS, BASAL HORMONAL LEVEL, THYROID STIMULATING HORMON, PROLACTIN
 
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