Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   AUGUST-SEPTEMBER 2007 , Volume 9 , Number 3 (38); Page(s) 7 To 12.
 
Paper: 

THE EFFECTS OF AQUEOUS EXTRACT OF TEUCRLUM POLIUM L. ON RAT GASTRIC ACID SECRETION IN BASAL, VAGOTOMIZED AND VAGAL STIMULATED CONDITIONS

 
 
Author(s):  NIAZMAND SAEID*, HAJZADEH M.A.R., KESHAVARZIPOUR TAFTI Z.
 
* MASHHAD UNIV. MEDICAL SCIENCES
 
Abstract: 
Background and Objective: Teucrium polium L. (Labiatae) is plant with antidiabetic, antispasmodic and antibacterial properties that its effects on gastric secretion have not been studied. The aim of this study was to investigate the effects of aqueous extract of Teucrium polium L. on rat gastric acid secretion in basal, vagotomized and vagal- stimulated conditions.
METHODS: Twenty four wistar rats weighed (200-250g) were randomly divided into two equal groups (case and control). After the anesthetization of animals by sodium thiopental (50 mg/kg, ip), tracheostomy, laparatomy and gastrodeodenostomy were done. Aqueous extract of her plant in 5, 10 and 20 mg/ml concentrations were prepared and gastric acid concentration was measured by titrator. The results in two groups were compared.
FINDINGS: The mean difference between first and second samples in case group were significant only in vagotomized condition (p<0.05). The comparison of three states showed that in vagotomizd Avs. basal condition and in vagotomized vs. vagal-stimulated condition, there were significant differences in acid secretion (p<0.05). The comparison between control and case group showed that there is no effect on gastric acid with aqueous extract of Teucrium poliwn L.
CONCLUSION: The results showed that different concentrations of aqueous extract of Teucrium polium between control and case groups in three conditionsv have no effect on acid secretion.
 
Keyword(s): TEUCRIUM POLIUM L., GASTRICA ACID, VAGOTOMY, VAGUS NERVE
 
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