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Paper Information

Journal:   IRANIAN POLYMER JOURNAL (ENGLISH)   2008 , Volume 17 , Number 4; Page(s) 273 To 280.
 
Paper: 

PREPARATION OF A DELAYED RELEASING DEVICE OF HYDROXYPROPYL METHYLCELLULOSE PHTHALATE MACROCAPSULES CONTAINING PEPPERMINT OIL

 
 
Author(s):  RAFATI HASAN*, NEZHADEBRAHIMI S., REZA DOUST H.
 
* MEDICINAL PLANT AND DRUGS RESEARCH INSTITUTE, SHAHID BEHESHTI UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

In this study, pH-sensitive macrocapsules containing peppermint oil (PO) were prepared using a new emulsification/polymer precipitation technique. An aqueous alkaline solution of hydroxypropyl methylcellulose phthalate (HPMCP) was used to emulsify PO in water (O/W). This emulsion was then added dropwise to a solution of citric acid to result in a solid dispersion of macrocapsules. Screening studies showed that three different factors including the polymer and the acid concentrations, as well as the essential oil to water (O/W) ratio have considerable effects on the encapsulation process. Different formulations of macrocapsules were prepared and characterized in terms of PO loading, encapsulation efficiency, and release using GC-FID analysis. A 2- level factorial design with 4-centre points was then used to optimize PO loading and encapsulation efficiency against the above mentioned parameters. Optical microscopy showed a polydispersed O/W emulsion, whereas the macrocapsules were uniformly dispersed with mean diameter of 1 mm. The prepared macrocapsules could protect PO from acidic condition of stomach and release it in a simulated intestinal fluid.

 
Keyword(s): DELAYED RELEASE, ENCAPSULATION, HPMCP, MACROCAPSULES, PEPPERMINT OIL, PH-SENSITIVE POLYMER
 
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