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Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   MARCH 2008 , Volume 5 , Number 1; Page(s) 67 To 73.
 
Paper: 

A CONVENIENT, RAPID AND ECO-FRIENDLY SYNTHESIS OF ISOXAZOLINE HETEROCYCLIC MOIETY CONTAINING BRIDGE AT 20-AMINE AS POTENTIAL PHARMACOLOGICAL AGENT

 
 
Author(s):  DESAI J.T.*, DESAI C.K., DESAI K.R.
 
* DEPARTMENT OF CHEMISTRY, VEER NARMAD SOUTH GUJARAT UNIVERSITY, UDHNA-MAGDALLA ROAD, SURAT (WEST) - 395007, GUJARAT STATE, INDIA
 
Abstract: 
2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH4OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, 1H NMR, 13C NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram - ve) and antifungal activity.
 
Keyword(s): COUMARIN, THIAZOLE, ISOXAZOLE, MICROWAVE TECHNIQUE, ANTIMICROBIAL ACTIVITY EVALUATION
 
References: 
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