Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2006 , Volume 63 , Number 12; Page(s) 998 To 1005.
 
Paper: 

EVALUATION OF SENSITIVITY AND SPECIFICITY OF CSF PROCALCITONIN LEVELS IN DIFFERENTIATION OF BACTERIAL AND VIRAL MENINGITIS, IN CHILDREN OLDER THAN TWO MONTHS, MARKAZ TEBBI HOSPITAL, 2003-2004

 
 
Author(s):  RAHIMI HAMID, SEDIGHI I., MAMISHI S., NOURBAKHSH SAMILEH, KADKHODAEI A., SIADATI AHMAD
 
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Abstract: 

Background: Bacterial meningitis is a fatal disease with high mortality and morbidity that needs emergency management. But due to nonspecific signs and symptoms it's diagnosis in children is difficult. Recently procalcitonin has been used for diagnosis of serious bacterial infections like bacterial meningitis. We conducted a prospective study in children for evaluation of procalcitonin in differential diagnosis of acute bacterial and viral meningitis. The aim of this study was the Evaluation of sensitivity and specificity of CSF proca1citonin levels in differentiation between bacterial and viral meningitis in children older than two months, in Markaz Tebbi hospital, during 1382-1383.
Materials and Methods: In a prospective process research, we measured CSF procalcitonin levels in 43 children older than two months referred to Markaz Tebbi hospital. According to the results of universal PCR the patients were divided into two groups: bacterial meningitis (n=11) and nonbacterial meningitis (n=32). To analysis the results, Mann-Whitney test was used.
Results: CSF proca1citonin level in bacterial meningitis was significantly higher than viral meningitis (1.72
±0.9ng/ml and 0.71±0.04 ng/ml respectively, P value= 0.00). A serum procalcitonin level> 0.5 ng/ml had high sensitivity and specificity (90.1% and 97.1% respectively) in the diagnosis of bacterial meningitis.
Conclusion: CSF procalcitonin level seems to be a valuable marker in differentiating between bacterial and viral meningitis.

 
Keyword(s): MENINGITIS, CHILDREN, PROCALCITONIN, UNIVERSAL PCR
 
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