Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2006 , Volume 63 , Number 12; Page(s) 961 To 964.
 
Paper: 

THE COMPARISON OF PROPOFOL & REMIFENTANIL WITH THIOPENTAL & REMIFENTANIL WITHOUT USING MUSCLE RELAXANT FOR HEMODYNAMIC RESPONSES AND INTUBATION CONDITIONS

 
 
Author(s):  SOLTANI MOHAMMADI S., TOUFIGHI F., SHOEYBI G.
 
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Abstract: 

Background: Tracheal intubation may be accomplished with remifentanil and a nonopioid intravenous anesthetic agent without a muscle relaxant. In this study, we compared propofol + remifentanil with thiopental + remifentanil without using muscle relaxant for hemodynamic responses and intubation conditions.
Materials and Methods: In 100 ASA class I and II patients scheduled for elective surgery less than 1 hour duration were randomly assigned to two equal groups. After premedication with midazolam 0.03
mg/kg intravenously, remifentanil 4mg/kg were given in each group. In group I, propofol 2.5mg/kg and in group II, thiopental 5mg/kg were given intravenously. After 90s, trachea was intubated. Intubation conditions were classified by the anesthesiologist performing the intubation as: excellent, good, fair and poor. Systolic, mean, diastolic arterial blood pressure and heart rate were recorded as baseline, after the induction and 1, 3, 5, 10, 15 min after the intubation. Data were analyzed by chi-square, independent t-test, paired t-test and fisher's exact test. P<0.05 was statistically significant.
Results: The tracheal intubation conditions were excellent in 60%, good in 32% and fair in 16% of group I and 42%, 42%, 16% in group II (p=0/166). In group I, 52% and in group II, 24% need intravenous ephedrine for treatment of hypotension (P=0.004). Atropine were given intravenously in 4 patients of group I and non of group II for bradycardia (P=0.059).
Conclusion: The results suggest that propofol 2.5 mg/kg + remifentanil 4
mg/kg compared with thiopental 5mg/kg + remifentanil 4mg/kg has no priority for tracheal intubation condition but with more hemodynamic changes.

 
Keyword(s): TRACHEAL INTUBATION, REMIFENTANIL, PROPOFOL
 
References: 
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