Paper Information

Journal:   JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   2006 , Volume - , Number 1 (36); Page(s) 27 To 33.
 
Paper: 

PRODUCTION AND QUALITY CONTROL OF SODIUM FLUORIDE (NA18F) AND IT'S DISTRIBUTION IN RATE’S LESIONS AS PET RADIOPHARMACEUTICAL FOR BONE SCAN

 
 
Author(s):  AKHLAGHI MAHDI*, MIRZAEI MOHAMMAD, JALILIAN AMIR REZA, SHADANPOUR N., MORADKHANI S., SADADI F., MOSTAN MAHSA, ASLANI GH.R., ENSAF M.R.
 
* NUCLEAR RESEARCH CENTER FOR AGRICULTURE AND MEDICINE, AEOI, KARAJ, IRAN
 
Abstract: 

Sodium fluoride (Na18F) is the positron emission tomography (PET) radiopharmaceutical for skeletal imaging. The fluoride-18 ions are produced in NRCAM cyclotron IBA, Cyclone-30 by bombardment of enriched water (H218O) with accelerated protons. The produced fluoride-18 ions are converted to injectable sodium fluoride solution. Then, the quality control of sodium fluoride solution is carried out with identification of the radionuclide, radiochemical and chemical purity, pyrogenicity and sterility. After the quality control, the sodium fluoride solution is injected into the rate’s lesion and the distribution of fluoride-18 ions is investigated with imaging by the use of a dual-headed coincidence system. In this paper the process and parameters of the production, methods of the quality the control, and the coincidence images of the rat's lesions and the distribution of fluoride-18 ions are described. The obtained images show that the maximum uptake of the fluoride-18 ions is in the bone lesions.

 
Keyword(s): SODIUM FLUORIDE (NA18F), FLUORIDE 18, BONE TISSUES, RADIOPHARMACEUTICALS, SKELETAL IMAGING, POSITRON EMISSION TOMOGRAPHY, ENRICHED WATER, QUALITY CONTROL, UPTAKE
 
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